4-Aminopyridine, CAS 504-24-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-pyridinamine

Purity: ≥95%

Formula Markup: C5H6N2

Formula Weight: 94.1

CAS Number: 504-24-5

Notes: 4-Aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+-channels (Kv proteins in the KCN gene family). It has greatest potency at Kv1 (KCNA) and Kv3 (KCNC) family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively).{29898} 4-AP also blocks Kv2 and Kv4 subunits at millimolar concentrations.{29898} When administered orally, 4-AP has benefits against multiple sclerosis, while injection into the brain produces epileptiform activity and can be used to study seizures.{29897,29899,29900}

• SKU: CAY18511-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18511-25
• Package Unit: 25 g
• Quantity Unit: STK