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Applications: Useful for inhibition of PD1:PD-L1 interactions.
Assay Conditions: 11.5 nM using PD-1:PD-L1[Biotinylated]Inhibitor Screening Assay Kit (BPS Bioscience,Cat. #72003) and human PD-1 and PD-L1. 1.8nM using mouse PD-L1 and mouse PD-1[Biotinylated].
Description: Neutralizing recombinant chimeric murine/human monoclonal antibody recognizing the extracellular domain of PD-L1 and blocking the binding of PD-L1 to PD-1. This antibody has been shown to cross-react with mouse PD-L1. No other species have been tested.
Endotoxin Level: <1 EU/µg
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Purification: Protein A affinity chromatographyfrom HEK293 supernatants.
Storage Stability: Stable for at least 12 months at-80°C.
Tags: None
Uniprot: Q9NZQ7
Warnings: Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.
Biosafety Level: Not applicable (BSL-1)
References: 1. Freeman, G.J., et al., J. Exp. Med. 2000; 192(7): 1027-1034.
2. Dong, H., et al., Nat. Med. 1999; 5(12): 1365-1369.
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