Clomethiazole, CAS 533-45-9

Product Description: Chlormethiazole is an potent and orally active GABAA agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].

Applications: Neuroscience-Neuromodulation

Formula: C6H8ClNS

References: [1]Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.Eur J Pharmacol. 2002 Oct 11;452(3):255-62./[2]Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44(8):1424-30

CAS Number: 533-45-9

Molecular Weight: 161.65

Compound Purity: 99.75

Research Area: Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Cytochrome P450;GABA Receptor

• SKU: MEXHY-129105-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-129105-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK