Product Description: DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].
Applications: Neuroscience-Neuromodulation
Formula: C8H9NO4
References: [1]Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9./[2]Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43.
CAS Number: 146255-66-5
Molecular Weight: 183.163
Compound Purity: 99.65
Research Area: Neurological Disease
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 1 mg/mL (ultrasonic)
Target: mGluR
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