DNA Base Excision Repair Pathway Inhibitor, CAS 6960-45-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 7-nitro-1H-indole-2-carboxylic acid

Purity: ≥98%

Formula Markup: C9H6N2O4

Formula Weight: 206.2

CAS Number: 6960-45-8

Notes: Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break.{26694} DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM).{26694,26697,26696} Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration.{26697} DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.{26697,26695}

• SKU: CAY16348-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16348-25
• Package Unit: 25 mg
• Quantity Unit: STK