Product Description: DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C22H27FN4O2
References: [1]James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22./[2]Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8(8):e69529.
CAS Number: 958233-07-3
Molecular Weight: 398.47
Compound Purity: 99.86
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: Others
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