HexylHIBO (hydrobromide)

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: a-amino-4-hexyl-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid, monohydrobromide

Purity: ≥98%

Formula Markup: C12H20N2O4 / HBr

Formula Weight: 337.21022

Notes: HexylHIBO is an antagonist of group I metabotropic glutamate receptors (mGluRs; Kbs = 140 and 110 µM for mGluR1α and mGluR5a, respectively).{68878} It is selective for group I mGluRs over mGluR2 (group II) and mGluR4a (group III) (Kbs = >1,000 µM for both), as well as AMPA, NMDA, and kainate receptors (IC50s = >100 µM for all). HexylHIBO (6.3 and 12.5 mg/kg, i.c.v.) inhibits NMDA-induced seizures in mice. It also potentiates increases in plasma adrenocorticotropic hormone (ACTH) levels in a rat model of restraint stress.{68879}

• SKU: CAY29164-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29164-10
• Package Unit: 10 mg
• Quantity Unit: STK