Structure and function of the complement system
The complement system is an important part of the immune system with a number of biological effects that mainly contribute to an inflammatory response and thus to the activation of cells such as leukocytes and endothelial cells.An intact complement system is essential for protection against infection. Nevertheless, this system is a double-edged sword: increased, uncontrolled or incorrect activation can potentially be dangerous to the patient.
The Svar complement system portfolio includes functional assays for all three pathways as well as activity markers in a simple ELISA format.
- Shortened hands-on time
- Safety checks for medicines and medical devices
- Neoepitope principle
Svar Complement TCC RUO
The new Svar Complement TCC is a flexible and easy to handle enzyme immunoassay for the detection of the terminal complement complex (TCC or sC5b-9) in human plasma.
Complement TCC is ideally suited for studies in basic and translational research, clinical assessment of therapy and safety studies for medical devices and drugs.
TCC occurs in all three complement pathways and is the end product of the terminal pathway for any determination of compliment activity.
1. Research: To enable effective therapies
The activity of the complement system is a key factor in the progression of many pathological conditions. Elevated TCC levels are detected in acute injury (sepsis, trauma ...) as well as in chronic inflammatory processes (SLE, RA, aHUS, ANCA ..).
2. Hemocompatibility: To provide safe therapies
Hemocompatibility testing is mandatory for assessing the interactions between foreign materials / foreign substances and blood.
Complement markers such as TCC are used to predict potential side effects of medical devices such as stents, bypass grafts, but also of biologics and in nanomedicine.
3. Drug safety: Prevention of side effects
Many patients have side effects that may be related to complement activation. TCC is an important parameter for evaluating if a drug is toxic or if it is related to an "infusion reaction".
Svar Complement C4d RUO
The Svar Complement C4d RUO Marker is specific for the classical and the lectin pathway of the complement system, which play a major role in transplantation medicine and autoimmune diagnostics.
This assay was designed to measure the C4d epitope without cross-reactivity with C4, C4b, C4c or other similar proteins.
Research and drug development:
C4d has long been used as a biomarker of compliment activity and is known for its stability and strong association with antibody-mediated graft rejection. Furthermore, C4d acts as an important biomarker for the prediction and monitoring of SLE, sclerosis and ANCA - associated vasculitis.
Studies show that C4d is also an important parameter in both the diagnosis and the prognosis of lung cancer.
- A variety of applications
- Easy to use
- Reliable and proven track record
- Accelerated drug development
- Improved patient safety