IRAK inhibitor 1, CAS 1042224-63-4

Product Description: IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

Applications: COVID-19-immunoregulation

Formula: C17H19N5

References: [1]Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5./[2]Li S, et al. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.

CAS Number: 1042224-63-4

Molecular Weight: 293.37

Compound Purity: 99.83

Research Area: Inflammation/Immunology

Solubility: DMSO : 16.67 mg/mL (ultrasonic)

Target: IRAK

• SKU: MEXHY-13275-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13275-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK