Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide
Purity: ≥98%
Formula Markup: C36H42N6O
Formula Weight: 574.8
CAS Number: 1793053-37-8
Notes: SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein.{21355,23894} LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM).{16441} It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous cell carcinoma cells stably expressing SMYD2 with an IC50 value of 0.6 µM.{16441} LLY-507 is >100-fold selective for SMYD2 over a panel of 27 protein methyltransferases and non-methyltransferase targets.{16441} See the Structural Genomics Consortium (SGC) website for more information.
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