Nelarabine, CAS 121032-29-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 9-ß-D-arabinofuranosyl-6-methoxy-9H-purin-2-amine

Purity: ≥98%

Formula Markup: C11H15N5O5

Formula Weight: 297.3

CAS Number: 121032-29-9

Notes: Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}

• SKU: CAY20248-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20248-10
• Package Unit: 10 mg
• Quantity Unit: STK