Background: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
Positive Control: Human kidney.
Immunogen: Synthetic peptide derived from the human PD1 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Shinohara, T., et al. ‘Structure and chromosomal localization of the human PD-1 gene (PDCD1)” Genomics, 23, 704-706 (1994)
2. Fife, B.T., Pauken, K.E. ‘The role of the PD-1 pathway in autoimmunity and peripheral tolerance.” Ann. N.Y. Acad. Sci., 1217, 45-59 (2011).
UniProt: Q15116.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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