Rabbit anti-ZEB1 Antibody Affinity Purified

Stock Concentration: 200 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein Ref Seq ID: NP_110378.3

Uniprot ID: P37275

Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.

Immunogen: Between 1074 and C-terminus

Physical State: Liquid

Purity: Antigen Affinity Purified

Antibody Registry ID: AB_1524126

• SKU: BEYA301-922A
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A301-922A
• Package Unit: 100 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Isotype: IgG
• Human Gene ID: 6935
• Host: Rabbit
• Conjugate: Unconjugated