Clone Name: MEM-238
Application Note: FACS: 20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 274
Specificity/Sensitivity: This antibody recognizes an epitope between amino acids 192-697 of CD222 (IGF2 receptor).
Form: Liquid
Buffer (with preservative): PBS, 15mM Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Uniprot ID: P11717
Antigen Species: Human
Immunogen: Recombinant Vaccinia virus encoding CD222.
Purification: Purified by size-exclusion chromatography
Conjugation: PE
Full Name: insulin like growth factor 2 receptor
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