CAY10796, CAS 404828-14-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-4-quinazolinamine

Purity: ≥98%

Formula Markup: C18H15N5

Formula Weight: 301.4

CAS Number: 404828-14-4

Notes: CAY10796 is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM.{40152} It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively.{40152,40153} In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with CAY10796 dose-dependently potentiates peak current densities.{40151}

• SKU: CAY21190-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21190-500
• Package Unit: 500 µg
• Quantity Unit: STK