Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]-phenol, monohydrochloride
Purity: ≥95%
Formula Markup: C21H18N2O3S / HCl
Formula Weight: 414.9
CAS Number: 2361799-64-4
Notes: DPTIP is an inhibitor of neutral sphingomyelinase 2 (nSMase2; IC50 = 30 nM).{45740} It is selective for nSMase2 over alkaline phosphatase (ALP) and acid sphingomyelinase (IC50s = >100 µM for both). DPTIP reduces viral yield in Vero and HeLa cells infected with West Nile virus (EC50s = 0.26 and 2.81 µM, respectively) or Zika virus (EC50s = 1.56 and 1.84 µM, respectively).{68890} It inhibits the secretion of extracellular vesicles from primary mouse astrocytes activated by FBS withdrawal in a concentration-dependent manner and prevents serum deprivation-induced astrocyte activation in primary rat astrocytes when used at a concentration of 10 µM.{45740} DPTIP (10 mg/kg) reduces IL-1β-induced extracellular vesicle release from astrocytes and decreases neutrophil infiltration to the brain in a model of inflammation-induced brain injury using GFAP-GFP mice. It reduces hepatic levels of chemokine (C-C motif) ligand 2 (Ccl2), Tnf-α, Il-6, and Il-1β in the same model.
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