Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (R)-2-(2-chloro-6-fluoro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)naphtho[2,3-d]oxazole-4,9-dione, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C22H16ClFN2O4 / XCF3COOH
Formula Weight: 426.8
Notes: SJB2-043 analog is an inhibitor of OTUB1 and ubiquitin-specific protease 8 (USP8; IC50s = 0.17 and 0.28 nM, respectively) and a derivative of the USP1/UAF1 complex and SARS-CoV-2 PLPro inhibitor SJB2-043 (Item No. 36605).{66880} It is selective for OTUB1 and USP8 over USP1, USP2, USP7, USP36, and ataxin-3 (IC50s = 1,370, 3,800, >10,000, 8,400, and >10,000 nM, respectively). SJB2-043 analog reduces viability in H1975, EBC-1, NCI H1703, H23, and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 118, 172, 145, 431, and 1,004 nM, respectively). In vivo, SJB2-043 analog (5 mg/kg twice daily) decreases tumor volume in an H1975 mouse xenograft model.
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